Timing and delay of radical prostatectomy do not lead to adverse oncologic outcomes: results from a large European cohort at the times of COVID-19 pandemic.
Identifieur interne : 000359 ( Main/Exploration ); précédent : 000358; suivant : 000360Timing and delay of radical prostatectomy do not lead to adverse oncologic outcomes: results from a large European cohort at the times of COVID-19 pandemic.
Auteurs : Romain Diamand [Belgique] ; Guillaume Ploussard [France] ; Mathieu Roumiguié [France] ; Marco Oderda [Italie] ; Daniel Benamran [Suisse] ; Gaelle Fiard [France] ; Alexandre Peltier [Belgique] ; Giuseppe Simone [Italie] ; Julien Van Damme [Belgique] ; Bernard Malavaud [France] ; Christophe Iselin [Suisse] ; Jean-Luc Descotes [France] ; Jean-Baptiste Roche [France] ; Thierry Quackels [Belgique] ; Thierry Roumeguère [Belgique] ; Simone Albisinni [Belgique]Source :
- World journal of urology [ 1433-8726 ] ; 2020.
Abstract
PURPOSE
The current COVID-19 pandemic is transforming our urologic practice and most urologic societies recommend to defer any surgical treatment for prostate cancer (PCa) patients. It is unclear whether a delay between diagnosis and surgical management (i.e., surgical delay) may have a detrimental effect on oncologic outcomes of PCa patients. The aim of the study was to assess the impact of surgical delay on oncologic outcomes.
METHODS
Data of 926 men undergoing radical prostatectomy across Europe for intermediate and high-risk PCa according to EAU classification were identified. Multivariable analysis using binary logistic regression and Cox proportional hazard model tested association between surgical delay and upgrading on final pathology, lymph-node invasion (LNI), pathological locally advanced disease (pT3-4 and/or pN1), need for adjuvant therapy, and biochemical recurrence. Kaplan-Meier analysis was used to estimate BCR-free survival after surgery as a function of surgical delay using a 3 month cut-off.
RESULTS
Median follow-up and surgical delay were 26 months (IQR 10-40) and 3 months (IQR 2-5), respectively. We did not find any significant association between surgical delay and oncologic outcomes when adjusted to pre- and post-operative variables. The lack of such association was observed across EAU risk categories.
CONCLUSION
Delay of several months did not appear to adversely impact oncologic results for intermediate and high-risk PCa, and support an attitude of deferring surgery in line with the current recommendation of urologic societies.
DOI: 10.1007/s00345-020-03402-w
PubMed: 32776243
PubMed Central: PMC7416303
Affiliations:
- Belgique, France, Italie, Suisse
- Aquitaine, Auvergne-Rhône-Alpes, Latium, Midi-Pyrénées, Nouvelle-Aquitaine, Occitanie (région administrative), Piémont, Rhône-Alpes, Région de Bruxelles-Capitale
- Bordeaux, Bruxelles, Grenoble, Rome, Toulouse, Turin
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Cancer Institute, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Urology Department, IRCCS "Regina Elena" National Cancer Institute, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Van Damme, Julien" sort="Van Damme, Julien" uniqKey="Van Damme J" first="Julien" last="Van Damme">Julien Van Damme</name><affiliation wicri:level="3"><nlm:affiliation>Urology Department, University Clinics Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Urology Department, University Clinics Saint-Luc, Université Catholique de Louvain, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Malavaud, Bernard" sort="Malavaud, Bernard" uniqKey="Malavaud B" first="Bernard" last="Malavaud">Bernard Malavaud</name><affiliation wicri:level="3"><nlm:affiliation>Urology Department, Institut Universitaire du Cancer Toulouse-Oncopole, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Urology Department, Institut Universitaire du Cancer Toulouse-Oncopole, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Iselin, Christophe" sort="Iselin, Christophe" uniqKey="Iselin C" first="Christophe" last="Iselin">Christophe Iselin</name><affiliation wicri:level="1"><nlm:affiliation>Urology Department, Hôpitaux Universitaires de Genève, Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Urology Department, Hôpitaux Universitaires de Genève, Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Descotes, Jean Luc" sort="Descotes, Jean Luc" uniqKey="Descotes J" first="Jean-Luc" last="Descotes">Jean-Luc Descotes</name><affiliation wicri:level="3"><nlm:affiliation>Urology Department, CHU de Grenoble, Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Urology Department, CHU de Grenoble, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Grenoble Alpes University, CNRS, Grenoble INP, TIMC-IMAG, Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Grenoble Alpes University, CNRS, Grenoble INP, TIMC-IMAG, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Roche, Jean Baptiste" sort="Roche, Jean Baptiste" uniqKey="Roche J" first="Jean-Baptiste" last="Roche">Jean-Baptiste Roche</name><affiliation wicri:level="3"><nlm:affiliation>Urology Department, Clinique Saint-Augustin, Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Urology Department, Clinique Saint-Augustin, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Quackels, Thierry" sort="Quackels, Thierry" uniqKey="Quackels T" first="Thierry" last="Quackels">Thierry Quackels</name><affiliation wicri:level="3"><nlm:affiliation>Urology Department, Hôpital Erasme, University Clinics of Brussels, Université Libre de Bruxelles, Route de Lennik 808, 1070, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Urology Department, Hôpital Erasme, University Clinics of Brussels, Université Libre de Bruxelles, Route de Lennik 808, 1070, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Roumeguere, Thierry" sort="Roumeguere, Thierry" uniqKey="Roumeguere T" first="Thierry" last="Roumeguère">Thierry Roumeguère</name><affiliation wicri:level="3"><nlm:affiliation>Urology Department, Hôpital Erasme, University Clinics of Brussels, Université Libre de Bruxelles, Route de Lennik 808, 1070, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Urology Department, Hôpital Erasme, University Clinics of Brussels, Université Libre de Bruxelles, Route de Lennik 808, 1070, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Albisinni, Simone" sort="Albisinni, Simone" uniqKey="Albisinni S" first="Simone" last="Albisinni">Simone Albisinni</name><affiliation wicri:level="3"><nlm:affiliation>Urology Department, Hôpital Erasme, University Clinics of Brussels, Université Libre de Bruxelles, Route de Lennik 808, 1070, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Urology Department, Hôpital Erasme, University Clinics of Brussels, Université Libre de Bruxelles, Route de Lennik 808, 1070, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32776243</idno><idno type="pmid">32776243</idno><idno type="doi">10.1007/s00345-020-03402-w</idno><idno type="pmc">PMC7416303</idno><idno type="wicri:Area/Main/Corpus">000658</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000658</idno><idno type="wicri:Area/Main/Curation">000658</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000658</idno><idno type="wicri:Area/Main/Exploration">000658</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Timing and delay of radical prostatectomy do not lead to adverse oncologic outcomes: results from a large European cohort at the times of COVID-19 pandemic.</title><author><name sortKey="Diamand, Romain" sort="Diamand, Romain" uniqKey="Diamand R" first="Romain" last="Diamand">Romain Diamand</name><affiliation wicri:level="3"><nlm:affiliation>Urology Department, Hôpital Erasme, University Clinics of Brussels, Université Libre de Bruxelles, Route de Lennik 808, 1070, Brussels, Belgium. romain.diamand@erasme.ulb.ac.be.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Urology Department, Hôpital Erasme, University Clinics of Brussels, Université Libre de Bruxelles, Route de Lennik 808, 1070, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Ploussard, Guillaume" sort="Ploussard, Guillaume" uniqKey="Ploussard G" first="Guillaume" last="Ploussard">Guillaume Ploussard</name><affiliation wicri:level="1"><nlm:affiliation>Urology Department, La Croix du Sud Hospital, Quint Fonsegrives, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Urology Department, La Croix du Sud Hospital, Quint Fonsegrives</wicri:regionArea><wicri:noRegion>Quint Fonsegrives</wicri:noRegion><wicri:noRegion>Quint Fonsegrives</wicri:noRegion></affiliation></author><author><name sortKey="Roumiguie, Mathieu" sort="Roumiguie, Mathieu" uniqKey="Roumiguie M" first="Mathieu" last="Roumiguié">Mathieu Roumiguié</name><affiliation wicri:level="3"><nlm:affiliation>Urology Department, CHU Toulouse, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Urology Department, CHU Toulouse, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Oderda, Marco" sort="Oderda, Marco" uniqKey="Oderda M" first="Marco" last="Oderda">Marco Oderda</name><affiliation wicri:level="3"><nlm:affiliation>Urology Department, Città della Salute e della Scienza di Torino, University of Turin, Turin, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Urology Department, Città della Salute e della Scienza di Torino, University of Turin, Turin</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Benamran, Daniel" sort="Benamran, Daniel" uniqKey="Benamran D" first="Daniel" last="Benamran">Daniel Benamran</name><affiliation wicri:level="1"><nlm:affiliation>Urology Department, Hôpitaux Universitaires de Genève, Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Urology Department, Hôpitaux Universitaires de Genève, Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Fiard, Gaelle" sort="Fiard, Gaelle" uniqKey="Fiard G" first="Gaelle" last="Fiard">Gaelle Fiard</name><affiliation wicri:level="3"><nlm:affiliation>Urology Department, CHU de Grenoble, Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Urology Department, CHU de Grenoble, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Grenoble Alpes University, CNRS, Grenoble INP, TIMC-IMAG, Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Grenoble Alpes University, CNRS, Grenoble INP, TIMC-IMAG, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Peltier, Alexandre" sort="Peltier, Alexandre" uniqKey="Peltier A" first="Alexandre" last="Peltier">Alexandre Peltier</name><affiliation wicri:level="3"><nlm:affiliation>Urology Department, Jules Bordet Institute, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Urology Department, Jules Bordet Institute, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Simone, Giuseppe" sort="Simone, Giuseppe" uniqKey="Simone G" first="Giuseppe" last="Simone">Giuseppe Simone</name><affiliation wicri:level="3"><nlm:affiliation>Urology Department, IRCCS "Regina Elena" National Cancer Institute, Rome, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Urology Department, IRCCS "Regina Elena" National Cancer Institute, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Van Damme, Julien" sort="Van Damme, Julien" uniqKey="Van Damme J" first="Julien" last="Van Damme">Julien Van Damme</name><affiliation wicri:level="3"><nlm:affiliation>Urology Department, University Clinics Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Urology Department, University Clinics Saint-Luc, Université Catholique de Louvain, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Malavaud, Bernard" sort="Malavaud, Bernard" uniqKey="Malavaud B" first="Bernard" last="Malavaud">Bernard Malavaud</name><affiliation wicri:level="3"><nlm:affiliation>Urology Department, Institut Universitaire du Cancer Toulouse-Oncopole, Toulouse, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Urology Department, Institut Universitaire du Cancer Toulouse-Oncopole, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Iselin, Christophe" sort="Iselin, Christophe" uniqKey="Iselin C" first="Christophe" last="Iselin">Christophe Iselin</name><affiliation wicri:level="1"><nlm:affiliation>Urology Department, Hôpitaux Universitaires de Genève, Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Urology Department, Hôpitaux Universitaires de Genève, Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Descotes, Jean Luc" sort="Descotes, Jean Luc" uniqKey="Descotes J" first="Jean-Luc" last="Descotes">Jean-Luc Descotes</name><affiliation wicri:level="3"><nlm:affiliation>Urology Department, CHU de Grenoble, Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Urology Department, CHU de Grenoble, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Grenoble Alpes University, CNRS, Grenoble INP, TIMC-IMAG, Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Grenoble Alpes University, CNRS, Grenoble INP, TIMC-IMAG, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Roche, Jean Baptiste" sort="Roche, Jean Baptiste" uniqKey="Roche J" first="Jean-Baptiste" last="Roche">Jean-Baptiste Roche</name><affiliation wicri:level="3"><nlm:affiliation>Urology Department, Clinique Saint-Augustin, Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Urology Department, Clinique Saint-Augustin, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Quackels, Thierry" sort="Quackels, Thierry" uniqKey="Quackels T" first="Thierry" last="Quackels">Thierry Quackels</name><affiliation wicri:level="3"><nlm:affiliation>Urology Department, Hôpital Erasme, University Clinics of Brussels, Université Libre de Bruxelles, Route de Lennik 808, 1070, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Urology Department, Hôpital Erasme, University Clinics of Brussels, Université Libre de Bruxelles, Route de Lennik 808, 1070, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Roumeguere, Thierry" sort="Roumeguere, Thierry" uniqKey="Roumeguere T" first="Thierry" last="Roumeguère">Thierry Roumeguère</name><affiliation wicri:level="3"><nlm:affiliation>Urology Department, Hôpital Erasme, University Clinics of Brussels, Université Libre de Bruxelles, Route de Lennik 808, 1070, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Urology Department, Hôpital Erasme, University Clinics of Brussels, Université Libre de Bruxelles, Route de Lennik 808, 1070, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Albisinni, Simone" sort="Albisinni, Simone" uniqKey="Albisinni S" first="Simone" last="Albisinni">Simone Albisinni</name><affiliation wicri:level="3"><nlm:affiliation>Urology Department, Hôpital Erasme, University Clinics of Brussels, Université Libre de Bruxelles, Route de Lennik 808, 1070, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Urology Department, Hôpital Erasme, University Clinics of Brussels, Université Libre de Bruxelles, Route de Lennik 808, 1070, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author></analytic><series><title level="j">World journal of urology</title><idno type="eISSN">1433-8726</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>PURPOSE</b></p><p>The current COVID-19 pandemic is transforming our urologic practice and most urologic societies recommend to defer any surgical treatment for prostate cancer (PCa) patients. It is unclear whether a delay between diagnosis and surgical management (i.e., surgical delay) may have a detrimental effect on oncologic outcomes of PCa patients. The aim of the study was to assess the impact of surgical delay on oncologic outcomes.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>Data of 926 men undergoing radical prostatectomy across Europe for intermediate and high-risk PCa according to EAU classification were identified. Multivariable analysis using binary logistic regression and Cox proportional hazard model tested association between surgical delay and upgrading on final pathology, lymph-node invasion (LNI), pathological locally advanced disease (pT3-4 and/or pN1), need for adjuvant therapy, and biochemical recurrence. Kaplan-Meier analysis was used to estimate BCR-free survival after surgery as a function of surgical delay using a 3 month cut-off.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Median follow-up and surgical delay were 26 months (IQR 10-40) and 3 months (IQR 2-5), respectively. We did not find any significant association between surgical delay and oncologic outcomes when adjusted to pre- and post-operative variables. The lack of such association was observed across EAU risk categories.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>Delay of several months did not appear to adversely impact oncologic results for intermediate and high-risk PCa, and support an attitude of deferring surgery in line with the current recommendation of urologic societies.</p></div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32776243</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>09</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1433-8726</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Aug</Month><Day>10</Day></PubDate></JournalIssue><Title>World journal of urology</Title><ISOAbbreviation>World J Urol</ISOAbbreviation></Journal><ArticleTitle>Timing and delay of radical prostatectomy do not lead to adverse oncologic outcomes: results from a large European cohort at the times of COVID-19 pandemic.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1007/s00345-020-03402-w</ELocationID><Abstract><AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">The current COVID-19 pandemic is transforming our urologic practice and most urologic societies recommend to defer any surgical treatment for prostate cancer (PCa) patients. It is unclear whether a delay between diagnosis and surgical management (i.e., surgical delay) may have a detrimental effect on oncologic outcomes of PCa patients. The aim of the study was to assess the impact of surgical delay on oncologic outcomes.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Data of 926 men undergoing radical prostatectomy across Europe for intermediate and high-risk PCa according to EAU classification were identified. Multivariable analysis using binary logistic regression and Cox proportional hazard model tested association between surgical delay and upgrading on final pathology, lymph-node invasion (LNI), pathological locally advanced disease (pT3-4 and/or pN1), need for adjuvant therapy, and biochemical recurrence. Kaplan-Meier analysis was used to estimate BCR-free survival after surgery as a function of surgical delay using a 3 month cut-off.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Median follow-up and surgical delay were 26 months (IQR 10-40) and 3 months (IQR 2-5), respectively. We did not find any significant association between surgical delay and oncologic outcomes when adjusted to pre- and post-operative variables. The lack of such association was observed across EAU risk categories.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Delay of several months did not appear to adversely impact oncologic results for intermediate and high-risk PCa, and support an attitude of deferring surgery in line with the current recommendation of urologic societies.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Diamand</LastName><ForeName>Romain</ForeName><Initials>R</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-2016-8543</Identifier><AffiliationInfo><Affiliation>Urology Department, Hôpital Erasme, University Clinics of Brussels, Université Libre de Bruxelles, Route de Lennik 808, 1070, Brussels, Belgium. romain.diamand@erasme.ulb.ac.be.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ploussard</LastName><ForeName>Guillaume</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Urology Department, La Croix du Sud Hospital, Quint Fonsegrives, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Roumiguié</LastName><ForeName>Mathieu</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Urology Department, CHU Toulouse, Toulouse, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Oderda</LastName><ForeName>Marco</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Urology Department, Città della Salute e della Scienza di Torino, University of Turin, Turin, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Benamran</LastName><ForeName>Daniel</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Urology Department, Hôpitaux Universitaires de Genève, Geneva, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fiard</LastName><ForeName>Gaelle</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Urology Department, CHU de Grenoble, Grenoble, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Grenoble Alpes University, CNRS, Grenoble INP, TIMC-IMAG, Grenoble, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peltier</LastName><ForeName>Alexandre</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Urology Department, Jules Bordet Institute, Brussels, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Simone</LastName><ForeName>Giuseppe</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Urology Department, IRCCS "Regina Elena" National Cancer Institute, Rome, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Van Damme</LastName><ForeName>Julien</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Urology Department, University Clinics Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Malavaud</LastName><ForeName>Bernard</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Urology Department, Institut Universitaire du Cancer Toulouse-Oncopole, Toulouse, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Iselin</LastName><ForeName>Christophe</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Urology Department, Hôpitaux Universitaires de Genève, Geneva, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Descotes</LastName><ForeName>Jean-Luc</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>Urology Department, CHU de Grenoble, Grenoble, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Grenoble Alpes University, CNRS, Grenoble INP, TIMC-IMAG, Grenoble, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Roche</LastName><ForeName>Jean-Baptiste</ForeName><Initials>JB</Initials><AffiliationInfo><Affiliation>Urology Department, Clinique Saint-Augustin, Bordeaux, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Quackels</LastName><ForeName>Thierry</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Urology Department, Hôpital Erasme, University Clinics of Brussels, Université Libre de Bruxelles, Route de Lennik 808, 1070, Brussels, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Roumeguère</LastName><ForeName>Thierry</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Urology Department, Hôpital Erasme, University Clinics of Brussels, Université Libre de Bruxelles, Route de Lennik 808, 1070, Brussels, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Albisinni</LastName><ForeName>Simone</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Urology Department, Hôpital Erasme, University Clinics of Brussels, Université Libre de Bruxelles, Route de Lennik 808, 1070, Brussels, Belgium.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>08</Month><Day>10</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>World J Urol</MedlineTA><NlmUniqueID>8307716</NlmUniqueID><ISSNLinking>0724-4983</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Biochemical recurrence</Keyword><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">Delay</Keyword><Keyword MajorTopicYN="N">Oncologic outcomes</Keyword><Keyword MajorTopicYN="N">Prostate cancer</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>06</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>08</Month><Day>03</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>8</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>8</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>8</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32776243</ArticleId><ArticleId IdType="doi">10.1007/s00345-020-03402-w</ArticleId><ArticleId IdType="pii">10.1007/s00345-020-03402-w</ArticleId><ArticleId IdType="pmc">PMC7416303</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Cancer. 2013 Jan 15;119(2):421-8</Citation><ArticleIdList><ArticleId IdType="pubmed">22786794</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur Urol. 2020 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IdType="pubmed">32356508</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Belgique</li><li>France</li><li>Italie</li><li>Suisse</li></country><region><li>Aquitaine</li><li>Auvergne-Rhône-Alpes</li><li>Latium</li><li>Midi-Pyrénées</li><li>Nouvelle-Aquitaine</li><li>Occitanie (région administrative)</li><li>Piémont</li><li>Rhône-Alpes</li><li>Région de Bruxelles-Capitale</li></region><settlement><li>Bordeaux</li><li>Bruxelles</li><li>Grenoble</li><li>Rome</li><li>Toulouse</li><li>Turin</li></settlement></list><tree><country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="Diamand, Romain" sort="Diamand, Romain" uniqKey="Diamand R" first="Romain" last="Diamand">Romain Diamand</name></region><name sortKey="Albisinni, Simone" sort="Albisinni, Simone" uniqKey="Albisinni S" first="Simone" last="Albisinni">Simone Albisinni</name><name sortKey="Peltier, Alexandre" sort="Peltier, Alexandre" uniqKey="Peltier A" first="Alexandre" last="Peltier">Alexandre Peltier</name><name sortKey="Quackels, Thierry" sort="Quackels, Thierry" uniqKey="Quackels T" first="Thierry" last="Quackels">Thierry Quackels</name><name sortKey="Roumeguere, Thierry" sort="Roumeguere, Thierry" uniqKey="Roumeguere T" first="Thierry" last="Roumeguère">Thierry Roumeguère</name><name sortKey="Van Damme, Julien" sort="Van Damme, Julien" uniqKey="Van Damme J" first="Julien" last="Van Damme">Julien Van Damme</name></country><country name="France"><noRegion><name sortKey="Ploussard, Guillaume" sort="Ploussard, Guillaume" uniqKey="Ploussard G" first="Guillaume" last="Ploussard">Guillaume Ploussard</name></noRegion><name sortKey="Descotes, Jean Luc" sort="Descotes, Jean Luc" uniqKey="Descotes J" first="Jean-Luc" last="Descotes">Jean-Luc Descotes</name><name sortKey="Descotes, Jean Luc" sort="Descotes, Jean Luc" uniqKey="Descotes J" first="Jean-Luc" last="Descotes">Jean-Luc Descotes</name><name sortKey="Fiard, Gaelle" sort="Fiard, Gaelle" uniqKey="Fiard G" first="Gaelle" last="Fiard">Gaelle Fiard</name><name sortKey="Fiard, Gaelle" sort="Fiard, Gaelle" uniqKey="Fiard G" first="Gaelle" last="Fiard">Gaelle Fiard</name><name sortKey="Malavaud, Bernard" sort="Malavaud, Bernard" uniqKey="Malavaud B" first="Bernard" last="Malavaud">Bernard Malavaud</name><name sortKey="Roche, Jean Baptiste" sort="Roche, Jean Baptiste" uniqKey="Roche J" first="Jean-Baptiste" last="Roche">Jean-Baptiste Roche</name><name sortKey="Roumiguie, Mathieu" sort="Roumiguie, Mathieu" uniqKey="Roumiguie M" first="Mathieu" last="Roumiguié">Mathieu Roumiguié</name></country><country name="Italie"><region name="Piémont"><name sortKey="Oderda, Marco" sort="Oderda, Marco" uniqKey="Oderda M" first="Marco" last="Oderda">Marco Oderda</name></region><name sortKey="Simone, Giuseppe" sort="Simone, Giuseppe" uniqKey="Simone G" first="Giuseppe" last="Simone">Giuseppe Simone</name></country><country name="Suisse"><noRegion><name sortKey="Benamran, Daniel" sort="Benamran, Daniel" uniqKey="Benamran D" first="Daniel" last="Benamran">Daniel Benamran</name></noRegion><name sortKey="Iselin, Christophe" sort="Iselin, Christophe" uniqKey="Iselin C" first="Christophe" last="Iselin">Christophe Iselin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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